Physicians in Wuhan, China, the epicenter for COVID-19 coronavirus that is now infecting human populations around the globe, report a shortage of test kits for this infectious pathogen. But maybe doctors rather than test for a virus ought to be testing for a viral vulnerability factor – an unstable form of haptoglobin (HAPTO-G), genetically prevalent in Asian populations. Then they wouldn’t be likely to run out of test kits as they are manufactured, in of all places, right there in Wuhan.
What is haptoglobin? (hap-tow-glow-bin) This blood protein binds to hemoglobin, the red protein in red blood cells that carries both oxygen and iron. By virtue of its binding power, haptoglobin mops up hemoglobin and loose iron when red blood cells die off so as to limit the availability of potentially destructive unbound iron. Haptoglobin also reduces the amount of iron lost in the kidneys and recycles it.
Out of three types of haptoglobin (HAPTO-G), one type doesn’t bind as well to hemoglobin, releases excess iron which then increases iron-induced oxidation (rusting), and increases oxidation (hardening) of cholesterol and degradation of vitamin C.
Oral vitamin C is rapidly excreted in urine flow (half-life of 30 minutes), which has caused some vitamin C skeptics to refer to vitamin C pills as nothing more than “expensive urine.”
Viruses increase demand for vitamin C. Oral vitamin C taken throughout the day would be necessary to maintain optimal blood levels among healthy patients, but that may not be achievable when viruses like the coronavirus take hold. The viral load increases exponentially as does the need for vitamin C, beyond what can be taken normally via oral dosing. Continuous vitamin C infusions may be required in severe life-threatening viral infections.
Vitamin C regeneration
Humans once internally produced vitamin C in their liver via enzymatic conversion of glucose sugar to ascorbate (aka vitamin C). All humans along with guinea pigs, fruit bats and primate monkeys have the same universal gene mutation and can’t endogenously secrete vitamin C due to a missing GULO enzyme (gulonolactone oxidase). Animals that secrete vitamin C internally are not sickened by coronaviruses.
That day may have arrived as a commercially branded vitamin C, FORMULA-216 (formulated by this author), has passed preliminary tests and raises blood levels of vitamin C on a 24/7 basis without consumption of fruits or vitamin pills.
Such 24/7 secretion of vitamin C during viral infections is critical to keep up with the viral load and replication rate, as viruses live inside healthy living cells and hijack their genetic machinery to replicate.
Researchers now await genetic tests to confirm the GULO gene has been re-activated. While the precise mechanism awaits confirmation, there is no question this novel form of supplemental vitamin C provides immune support and can stand up to the worst infections. It would be most beneficial to Asian populations and contains additional natural stabilizers that mop up loose iron to protect vitamin C from oxidation.