Abstract
Resveratrol,
a polyphenolic compound, is a powerful antioxidant with remarkable
anti-inflammatory properties. Inflammation and pain plays an important role in
the pathogenesis of knee osteoarthritis (OA) and could cause tissue damage and
morbidity. The aim of this study was to evaluate the anti-inflammatory and pain
reduction activities of orally administered resveratrol in patients with knee
OA. We carried out a 90-day pilot study to evaluate the ability of orally administered
resveratrol, as an adjuvant with meloxicam, to decrease knee joint pain and
biomarkers of inflammation in comparison with a placebo. One hundred ten men
and women (45-75 years old) diagnosed with mild to moderate knee OA were
treated with 15 mg per day meloxicam and either 500 mg per day resveratrol or
placebo for 90 days in a double-blind, randomized control trial. Pain severity
was evaluated at the beginning and at the end of treatment using Visual
Analogue Scale-100 scores. Fasting blood was collected to determine serum
interleukins 1β and 6, tumor necrosis factor-α, C-reactive protein, and
complement proteins C3 and C4. The resveratrol-treated group experienced a
time-dependent significant decrease in pain severity (P < .001). Serum levels
of the biochemical markers were significantly reduced compared with the
placebo-treated group (P < .01). These findings suggest that resveratrol may
be an effective "add-on" option with meloxicam in the treatment of
patients with mild to moderate knee OA.
Keywords: inflammatory markers; knee OA; knee pain; meloxicam;
resveratrol.
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