The collapse of the Selective Turnover Coefficient (d) from the ancient hominin baseline of 0.86 down to a modern level of 0.015 represents the functional shutdown of natural selection’s primary mechanism for the human race. For hundreds of thousands of years, high mortality rates before reproductive age served as an unyielding purifying filter, culling highly deleterious mutations and maintaining the structural integrity of our species’ code. By effectively reducing this mortality barrier by over 99% through modern sanitation, medicine, and infrastructure, humanity has unplugged its biological safety valve. Without this selective cleansing, the human genome is now entirely defenseless against a relentless, generation-by-generation influx of genetic errors, transforming our collective gene pool into a one-way accumulation sink for deleterious mutations.......
This 15-to-19 percent calculated degradation is a structural floor calculated solely on the mathematical basis of the collapse of d, meaning any negative impacts from modern chemistry or lifestyle only serve to further aggravate a species reproductive engine that is already operating less efficiently than before due to an unselected genetic load.
If you want to learn more about this, the science is developed in THE FROZEN GENE.